赛事中心穿越火线官方网站:刘杰
刘杰 教授/博导/院长助理
赛事中心穿越火线官方网站 赛事中心穿越火线官方网站
广东省深圳市光明区赛事中心穿越火线官方网站医学园2栋
赛事中心穿越火线官方网站教授/博导，赛事中心穿越火线官方网站院长助理，美国耶鲁大学博士，广东省青年拔尖人才、深圳市鹏城学者B类、广州市珠江科技新星，中国生物材料学会再生医学材料分会委员、中国生物材料学会生物材料先进制造分会委员、广东省生物医学工程学会理事兼副秘书长、广东省精准医学会类器官与器官芯片分会副主委、广东省精准医学会精准医美分会副主委。主持包括国家科技部重点研发、国家自然科学基金面上项目、广东省科技厅国际合作项目等20余项课题，在Nature Materials、Advanced Science、Biomaterials、ACS Nano等国际著名杂志发表研究论文80余篇，单篇论文引用最高350余次；获授权专利10余项，成果转化2项。研究方向包括：类器官与器官芯片；纳米材料用于药物递送和基因治疗；干细胞与再生医学。
一、学习、工作履历 （时间由近及远）
2021.02至今 赛事中心穿越火线官方网站赛事中心穿越火线官方网站 生物医学工程 教授
2016.08-2017.08 美国耶鲁大学医赛事中心穿越火线官方网站 神经外科与生物医学工程 访问学者
2014.06-2021.01 赛事中心穿越火线官方网站赛事中心穿越火线官方网站 生物医学工程 副教授
2010.10-2014.05 赛事中心穿越火线官方网站工赛事中心穿越火线官方网站 生物医学工程 “百人计划”讲师
2007.10-2009.10 美国耶鲁大学工赛事中心穿越火线官方网站 生物医学工程 博士
2007.01-2010.09 华中科技大学生命赛事中心穿越火线官方网站 生物材料与组织工程 博士
2004.09-2006.12 华中科技大学生命赛事中心穿越火线官方网站 生物医学工程 硕士
2000.09-2004.07 华中科技大学生命赛事中心穿越火线官方网站 生物医学工程 学士
二、研究方向
1.靶向纳米药物递送体系：针对恶性肿瘤治疗，采用合成高分子材料或外泌体等，开发系列能够用于癌症治疗的纳米药物、诊疗一体化体系，为肿瘤的靶向治疗提供新的方法和策略；
2.类器官与器官芯片：基于肿瘤、正常组织等类器官，结合3D打印、微流控技术以及类器官技术，开发能够用于药物或纳米材料评价的体外类组织器官。
3.干细胞与再生医学：基于改性生物材料构建可用于组织粘附、止血、修复的先进水凝胶体系、干细胞水凝胶体系以及3D生物打印水凝胶体系等。
4.科研项目
作为项目负责人(PI)主持的科研项目：
[1].国家重点研发计划，2023-2027
[2].深圳市科创委重点项目，2023-2025
[3].广东省自然科学基金面上项目，2022-2024
[4].国家自然科学基金面上项目，2018-2021
[5].深圳市基础研究专项面上项目，2020-2023
[6].广东省自然科学基金研究团队项目，2015-2020
[7].广东省科技计划国际合作项目，2015-2017
5.代表性论文
[1].Jiangbing Zhou, Jie Liu(共同第一作者), Christopher J. Cheng, Toral R. Patel, Caroline E.Weller, Joseph M. Piepmeier, Zhaozhong Jiang and W. Mark Saltzman*. Biodegradable poly(amine-co-ester) terpolymers for targeted gene delivery. Nature Materials, 2012, 11: 82-90
[2].Rui Dai, Wei Chen, You Chen, Jinlong Jin, Shiwei Zhang, Changhua Zhang? and Jie Liu?, 3D bioprinting platform development for high-throughput cancer organoid models construction and drug evaluation. Biofabrication, 2024, 16, 035026
[3].Yongchun Li, You Chen, Yifan Xue, Jinlong Jin, Yixin Xu, Weian Zeng, Jie Liu* and Jingdun Xie*. Injectable Hydrogel Delivery System with High Drug Loading for Prolonging Local Anesthesia. Advanced Science, 2024, 2309482
[4].Yifan Xue, Kaijin Chen, You Chen, Yadong Liu, Junjie Tang, Xiaoge Zhang, and Jie Liu*, Engineering Diselenide-IR780 Homodimeric Nanoassemblies with Enhanced Photodynamic and Immunotherapeutic Effects for Triple-Negative Breast Cancer Treatment. ACS Nano, 2023, 17, 22, 22553–22570
[5].Lili Cheng, Peng Zhang, Yadong Liu, Zhuoyin Liu, Junjie Tang, Langtao Xu, Jie Liu*, Multifunctional hybrid exosomes enhanced cancer chemo-immunotherapy by activating the STING pathway. Biomaterials, 2023, 301, 122259
[6].Bowen Zheng, Peng Zhang, Qijun Lv, Tao Wu, Yadong Li, Junjie Tang, Yanping Ma, Lili Cheng, Langtao Xu, Yizhen Wang, Yifan Xue, Jie Liu*, Jie Ren*. Development and preclinical evaluation of multifunctional hydrogel for precise thermal protection during thermal ablation. Bioactive Materials, 2024, 31, 119–135
[7].Qijun Lv, Yizhen Wang, Zhiyong Xiong, Yifan Xue, Jiajun Li, Moyang Chen, Kaijian Zhou, Hetao Xu, Xiaoge Zhang, Jie Liu?, Jie Ren?, Bo Liu?, Microvascularized tumor assembloids model for drug delivery evaluation in colorectal cancer-derived peritoneal metastasis，Acta Biomaterialia，2023, 168, 346–360
[8].Baizhu Chen, Xiaoge Zhang, Lili Cheng, Xiaomei Chen, Junjie Tang, Peng Zhang, Chen Wang, Jie Liu*. Surface programmed bacteria as photo-controlled NO generator for tumor immunological and gas therapy. Journal of Controlled Release, 2023, 353, 889–902
[9].You Chen, Yifan Xue, Langtao Xu, Weilin Li, Yiling Chen, Shunan Zheng, Rui Dai, Jie Liu*. Recapitulation of dynamic nanoparticle transport around tumor using a triangular multi-chamber tumor-on-a-chip. Lab on a Chip, 2022, 22, 4191 - 4204
[10].Langtao Xu, You Chen, Peng Zhang, Junjie Tang, Yifan Xue, Hongsheng Luo, Rui Dai, Jinlong Jin and Jie Liu*. 3D printed heterogeneous hybrid hydrogel scaffolds for sequential tumor photothermalchemotherapy and wound healing. Biomaterials Science, 2022, 10, 5648-5661
[11].You Chen, Langtao Xu, Weilin Li, Wanqi Chen, Qiubei He, Xiaoge Zhang, Junjie Tang, Yizhen Wang, Bo Liu and Jie Liu*. 3D bioprinted tumor model with extracellular matrix enhanced bioinks for nanoparticle evaluation. Biofabrication, 2022, 14, 025002
[12].JunJie Tang, Xiaoge Zhang, Lili Cheng, Yadong Liu, You Chen, Zhaozhong Jiang**, Jie Liu*. Multiple stimuli-responsive nanosystem for potent, ROS-amplifying, chemo-sonodynamic antitumor therapy. Bioactive Materials, 2022, 15, 355-371
[13].Xiaoge Zhang, Lili Cheng, Yao Lu, Junjie Tang, Qijun Lv, Xiaomei Chen, You Chen, Jie Liu*. A MXene-Based Bionic Cascaded-Enzyme Nanoreactor for Tumor Phototherapy/Enzyme Dynamic Therapy and Hypoxia-Activated Chemotherapy. Nano-Micro Letters, 2022, 14, 22
[14].Lili Cheng, Xiaoge Zhang, Junjie Tang, Qijun Lv, Jie Liu*, Gene-engineered exosomes-thermosensitive liposomes hybrid nanovesicles by the blockade of CD47 signal for combined photothermal therapy and cancer immunotherapy. Biomaterials, 2021, 275, 120964
[15].Man Shu, Junjie Tang, Lili Chen, Qiang Zeng, Chao Li, Shuting Xiao, Zhaozhong Jiang*, Jie Liu*. Tumor microenvironment triple-responsive nanoparticles enable enhanced tumor penetration and synergetic chemo-photodynamic therapy. Biomaterials, 2021, 268, 120574
[16].Xiaoge Zhang, Junjie Tang, Chao Li, Yao Lu, Lili Cheng, Jie Liu*. A targeting black phosphorus nanoparticle based immune cells nano-regulator for photodynamic/photothermal and photo-immunotherapy. Bioactive Materials, 2021, 6(2), 472-489
[17].You Chen, Weilin Li, Chao Zhang, Zhaoying Wu* and Jie Liu*. Recent Developments of Biomaterials for Additive Manufacturing of Bone Scaffolds. Advanced Healthcare Materials, 2020, 9(23), 2000724
[18].Qijun Lv, Lili Cheng, Yao Lu, Xiaoge Zhang, Yizhen Wang, Junfeng Deng, Jiangbing Zhou,* Bo Liu,* and Jie Liu*. Thermosensitive Exosome–Liposome Hybrid Nanoparticle-Mediated Chemoimmunotherapy for Improved Treatment of Metastatic Peritoneal Cancer. Advanced Science, 202000515, 1-13
[19].Shuting Xiao, Yao Lu, Miao Feng, Ming Dong, Zhong Cao, Xiaoge Zhang, You Chen, Jie Liu*. Multifunctional FeS2 theranostic nanoparticles for photothermal-enhanced chemodynamic/photodynamic cancer therapy and photoacoustic imaging. Chemical Engineering Journal, 2020, 396, 125294
